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| Player | EPA per Play | Rush Attempts | Rushing Yards | Rushing TDS |
|---|---|---|---|---|
| Audric Estimé | 0.102 | 46 | 198 | 1 |
| Blake Corum | 0.084 | 171 | 865 | 6 |
| Rachaad White | 0.078 | 133 | 572 | 4 |
| Chris Rodriguez Jr. | 0.055 | 112 | 500 | 6 |
| Raheim Sanders | 0.033 | 27 | 92 | 1 |
| J.K. Dobbins | 0.027 | 153 | 772 | 4 |
| DJ Giddens | 0.001 | 26 | 96 | 0 |
| Zach Charbonnet | -0.006 | 190 | 752 | 12 |
| Trey Benson | -0.007 | 29 | 160 | 0 |
| Omarion Hampton | -0.012 | 125 | 544 | 4 |
| Aaron Jones | -0.018 | 132 | 548 | 2 |
| Devin Singletary | -0.023 | 119 | 437 | 5 |
| Kenneth Walker III | -0.035 | 286 | 1340 | 9 |
| Jaret Patterson | -0.035 | 41 | 159 | 1 |
| Tyrone Tracy Jr. | -0.056 | 176 | 740 | 2 |
| Travis Etienne | -0.060 | 270 | 1174 | 7 |
| Kendre Miller | -0.062 | 47 | 193 | 1 |
| Emanuel Wilson | -0.062 | 126 | 499 | 3 |
| Nick Chubb | -0.063 | 136 | 568 | 3 |
| Michael Carter | -0.074 | 92 | 333 | 1 |
| Tyler Allgeier | -0.081 | 143 | 514 | 8 |
| Austin Ekeler | -0.083 | 14 | 43 | 0 |
| Saquon Barkley | -0.089 | 307 | 1248 | 7 |
| Quinshon Judkins | -0.109 | 231 | 829 | 7 |
| Isiah Pacheco | -0.116 | 118 | 462 | 1 |