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| Player | Avg Separation |
|---|---|
| Khalil Shakir | 3.754 |
| Zay Flowers | 3.644 |
| Wan'Dale Robinson | 3.429 |
| Justin Jefferson | 3.200 |
| Ja'Marr Chase | 3.031 |
| Amon-Ra St. Brown | 3.025 |
| DeVonta Smith | 3.014 |
| Jaxon Smith-Njigba | 2.978 |
| Chris Olave | 2.940 |
| Stefon Diggs | 2.815 |
| Puka Nacua | 2.811 |
| Keenan Allen | 2.631 |
| George Pickens | 2.450 |
| Courtland Sutton | 2.373 |
| A.J. Brown | 2.131 |