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Top 5 by EPA per Play: 1. Jahmyr Gibbs (0.153 EPA per Play); 2. Derrick Henry (0.129 EPA per Play); 3. Bucky Irving (0.088 EPA per Play); 4. Tyler Goodson (0.084 EPA per Play); 5. Saquon Barkley (0.077 EPA per Play).
| # | Player | EPA per Play | Rush Attempts | Rushing Yards | Rushing TDS |
|---|---|---|---|---|---|
| 1 | Jahmyr Gibbs | 0.153 | 264 | 1,517 | 18 |
| 2 | Derrick Henry | 0.129 | 367 | 2,191 | 20 |
| 3 | Bucky Irving | 0.088 | 224 | 1,199 | 8 |
| 4 | Tyler Goodson | 0.084 | 32 | 153 | 1 |
| 5 | Saquon Barkley | 0.077 | 439 | 2,510 | 19 |
| 6 | James Cook | 0.075 | 260 | 1,281 | 19 |
| 7 | Bijan Robinson | 0.059 | 305 | 1,458 | 14 |
| 8 | Isaac Guerendo | 0.058 | 84 | 420 | 4 |
| 9 | Jerome Ford | 0.048 | 104 | 565 | 3 |
| 10 | Chuba Hubbard | 0.043 | 251 | 1,197 | 10 |
| 11 | Tyler Allgeier | 0.040 | 138 | 646 | 3 |
| 12 | Patrick Taylor | 0.030 | 40 | 183 | 1 |
| 13 | Kareem Hunt | 0.012 | 228 | 845 | 9 |
| 14 | Sincere McCormick | 0.011 | 39 | 183 | 0 |
| 15 | J.K. Dobbins | 0.008 | 204 | 931 | 9 |
| 16 | Austin Ekeler | 0.008 | 99 | 456 | 4 |
| 17 | James Conner | 0.005 | 239 | 1,098 | 9 |
| 18 | Tank Bigsby | -0.005 | 168 | 766 | 7 |
| 19 | Michael Carter | -0.014 | 35 | 131 | 1 |
| 20 | Chase Brown | -0.021 | 230 | 992 | 7 |
| 21 | Jaleel McLaughlin | -0.024 | 115 | 494 | 1 |
| 22 | Ray Davis | -0.031 | 120 | 478 | 4 |
| 23 | Jordan Mason | -0.036 | 153 | 789 | 3 |
| 24 | Rico Dowdle | -0.045 | 235 | 1,079 | 2 |
| 25 | David Montgomery | -0.049 | 193 | 803 | 13 |